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What collagen really does in mature skin - Dr Frances Pitsilis, Skinfresh

Written by Frances Pitsilis | 6 March 2026

 

 

BUILDING COLLAGEN WITH AGE REQUIRES AN ORGANISED APPROACH

 

Collagen is one of the most talked-about words in skincare — but what does it actually do, especially in mature skin?

The Foundation of Firm, Healthy Skin

 

Collagen is the structural protein that gives skin its firmness, resilience, and smooth texture. Think of it as the internal scaffolding that keeps the skin lifted and supported. In younger years, collagen is produced efficiently, allowing skin to appear plump, elastic, and naturally radiant.

 

From our mid-30s onward, collagen production gradually declines. By menopause, this loss accelerates due to hormonal changes, particularly reduced oestrogen levels. The result is not simply wrinkles — it is a deeper structural shift. Skin becomes thinner, less elastic, and slower to repair. The jawline may soften, pores appear more visible, and fine lines settle more easily.

Why Collagen Matters Beyond Appearance

 

Collagen is not only about how skin looks; it is essential for how skin functions. Healthy collagen supports hydration, strength, and healing. As levels decline, the skin barrier weakens, making mature skin more prone to dryness, sensitivity, and inflammation.

 

This is why many women notice their skin suddenly behaving differently in their 40s and 50s — products that once worked no longer feel sufficient because the underlying structure has changed.

Supporting Natural Collagen Renewal

 

Many creams claim to “replace” collagen, but topical skincare mainly protects existing collagen rather than rebuilding significant amounts. True renewal occurs deeper within the skin, where fibroblast cells produce new collagen.

 

At Skinfresh, we take a medical approach to collagen stimulation, using evidence-based treatments designed to activate natural regeneration rather than create artificial change. The aim is stronger, healthier skin that looks refreshed, balanced, and authentically you.

 

Treatments start from internal health. Then targeted skincare including Dr Frances' exclusive Formula 68 Limited Edition night cream containing supra maximal strength anti ageing ingredients.

 

Then consider some of the extensive energy based treatments the clinic has like Titan, Limelight IPL, Laser Genesis, Exion - yes the clinic is highly  equipped with technology. 

 

The clinic also has extensive injectables for longer term assistance like Profhilo and Sunekos. 

 

For instant results that stimulate collagen production by 140% use dermal fillers - this is a very satisfying treatment. 

The Skinfresh Philosophy

 

At Skinfresh, we believe aesthetic medicine should enhance health as well as appearance. Our philosophy combines medical expertise, hormonal understanding, and advanced skin technology to support skin from the inside out. We focus on natural results, long-term skin quality, and personalised care — helping every woman look vibrant, confident, and well at every stage of life.